High quality α-Ketoglutaric acid, CAS 328-50-7 supplier
α-Ketoglutaric acid is also called 2-Ketoglutaric acid, alpha-Ketoglutaric acid or 2-Oxoglutaric acid. White powder. We are high qulity α-Ketoglutaric acid manufacturer and supplier. If you want to bulk buy α-Ketoglutaric acid, please contact us. α-Ketoglutaric acid price is reasonable.
Function of α-Ketoglutaric acid (CAS 328-50-7)
Krebs cycle
α-Ketoglutaric acid is an important metabolic intermediate in the microbial krebs cycle, is the key node to connect the carbon nitrogen metabolism in the cell. Position in the cycle is after isocitric acid and before succinyl coenzyme A. In this part, the remedial reaction can produce alpha -ketoglutaric acid through the transamination of glutamate to supplement the intermediate metabolite. This can also be achieved by glutamate dehydrogenase acting on glutamic acid.
Amino acid generation
Glutamic acid can produce glutamine under the action of glutamine synthase. The enzyme uses a molecule of ATP to produce glutamyl phosphate. This intermediate product is attacked by ammonia as a nucleophile, resulting in the formation of glutamine and inorganic phosphoric acid.
Dietary supplements
Alpha-ketoglutaric acid is sold as a dietary supplement. The trade name is AKG or α-KG, which is sold to fitness enthusiasts or bodybuilders. The seller claims that this substance can improve the performance at the peak of training. The seller claims that this is based on “studies have shown that too much ammonia can be combined with alpha-ketoglutaric acid to be taken away to reduce the numerous problems caused by ammonia poisoning”. However, the only study showing that alpha-ketoglutaric acid can reduce ammonia poisoning is the only one used for patients who have undergone hemodialysis.
Uses and applications of α-Ketoglutaric acid (CAS 328-50-7)
- α-Ketoglutaric acid is mainly used as a component of sports nutrition drinks.
- Used as an organic intermediate and a biochemical reagent.
- An analytical reagent for tryptophan; a substrate for the determination of amino converting enzyme and dehydrogenase; a matching reagent for the determination of liver function.
- Used as raw materials for medical and health care products, food additives.
- Reduce the body wastage of postoperative patients and long-term patients.
- In the brain, it acts as a precursor of tyrosine and glutamate. (α-Ketoglutaric acid can produce glutamic acid by transamination.)
- α-Ketoglutaric acid also has the effect of cyanide resistance. The experiment showed that the combination of sodium nitrite and sodium thiosulfate can improve the ability of anti cyanide and have anticonvulsant effect.
Production method of α-Ketoglutaric acid (CAS 328-50-7)
Mixing 225g oxalosuccinic acid with 600 ml concentrated hydrochloric acid for overnight use. Distillation concentration to 140℃, and the residues are cooled and crystallized. Getting 110-112 g of α-Ketoglutaric acid, and the yield is 92%-93%.
Related categories
Pharmaceutical intermediates; aliphatics; organic acids; amino acids; food additives; oxo-compound; pharm raw material; active pharmaceutical ingredient; general reagents; intermediate; vitamins and amino acids; microorganism; nutrition; carboxylic acid; pharmaceutical raw materials.
